A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effect of Previous Chemotherapy on the Quality of Cryopreserved Human Ovarian Tissue In Vitro
Tekijät: Azarbaijani BA, Sheikhi M, Oskam IC, Nurmio M, Laine T, Tinkanen H, Makinen S, Tanbo TG, Hovatta O, Jahnukainen K
Kustantaja: PUBLIC LIBRARY SCIENCE
Julkaisuvuosi: 2015
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: PLOS ONE
Lehden akronyymi: PLOS ONE
Artikkelin numero: ARTN e0133985
Vuosikerta: 10
Numero: 7
Sivujen määrä: 13
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0133985
This study provides quantitative in vitro evidence of the impact of chemotherapy on developmental capacity of cryopreserved human ovarian tissue. The results indicate that fertility preservation should be carried out, if possible, before initiation of alkylating agents in order to guarantee better in vitro survival of ovarian follicles. In addition, ovarian samples from younger girls show lower viability and fewer developing follicles in culture.
