A1 Refereed original research article in a scientific journal

Effect of Previous Chemotherapy on the Quality of Cryopreserved Human Ovarian Tissue In Vitro



Authors: Azarbaijani BA, Sheikhi M, Oskam IC, Nurmio M, Laine T, Tinkanen H, Makinen S, Tanbo TG, Hovatta O, Jahnukainen K

Publisher: PUBLIC LIBRARY SCIENCE

Publication year: 2015

Journal: PLoS ONE

Journal name in source: PLOS ONE

Journal acronym: PLOS ONE

Article number: ARTN e0133985

Volume: 10

Issue: 7

Number of pages: 13

ISSN: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0133985


Abstract

This study provides quantitative in vitro evidence of the impact of chemotherapy on developmental capacity of cryopreserved human ovarian tissue. The results indicate that fertility preservation should be carried out, if possible, before initiation of alkylating agents in order to guarantee better in vitro survival of ovarian follicles. In addition, ovarian samples from younger girls show lower viability and fewer developing follicles in culture.




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