A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Performance Evaluation of a Semi-automated Method for [F-18]FDG Uptake in Abdominal Visceral Adipose Tissue
Tekijät: Stefanie A. de Boer, Daan S. Spoor, Riemer H. J. A. Slart, Douwe J. Mulder, Melanie Reijrink, Ronald J. H. Borra, Gerbrand M. Kramer, Otto S. Hoekstra, Ronald Boellaard, Marcel J. Greuter
Kustantaja: SPRINGER
Julkaisuvuosi: 2019
Journal: Molecular Imaging and Biology
Tietokannassa oleva lehden nimi: MOLECULAR IMAGING AND BIOLOGY
Lehden akronyymi: MOL IMAGING BIOL
Vuosikerta: 21
Numero: 1
Aloitussivu: 159
Lopetussivu: 167
Sivujen määrä: 9
ISSN: 1536-1632
eISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-018-1211-1
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/39705558
PurposeSeverity of abdominal obesity and possibly levels of metabolic activity of abdominal visceral adipose tissue (VAT) are associated with an increased risk for cardiovascular disease (CVD). In this context, the purpose of the current study was to evaluate the reproducibility and repeatability of a semi-automated method for assessment of the metabolic activity of VAT using 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) positron emission tomography (PET)/x-ray computed tomography (CT).
ProceduresTen patients with lung cancer who underwent two baseline whole-body [F-18]FDG PET/low-dose (LD) CT scans within 1week were included. Abdominal VAT was automatically segmented using CT between levels L1-L5. The initial CT-based segmentation was further optimized using PET data with a standardized uptake value (SUV) threshold approach (range 1.0-2.5) and morphological erosion (range 0-5 pixels). The [F-18]FDG uptake in SUV that was measured by the automated method was compared with manual analysis. The reproducibility and repeatability were quantified using intraclass correlation coefficients (ICCs).
ResultsThe metabolic assessment of VAT on [F-18]FDG PET/LDCT scans expressed as SUVmean, using an automated method showed high inter and intra observer (all ICCs >0.99) and overall repeatability (ICC=0.98). The manual method showed reproducible inter observer (all ICCs >0.92), but less intra observer (ICC=0.57) and less overall repeatability (ICC=0.78) compared with the automated method.
ConclusionsOur proposed semi-automated method provided reproducible and repeatable quantitative analysis of [F-18]FDG uptake in VAT. We expect this method to aid future research regarding the role of VAT in development of CVD.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
