Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

: Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K

Publisher: SPRINGER HEIDELBERG

: 2015

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 71

: 3

: 321

: 327

: 7

: 0031-6970

: 1432-1041

DOI: https://doi.org/10.1007/s00228-014-1799-2

Terbinafine may reduce the opioid effect of tramadol and increase the risk of its monoaminergic adverse effects. Itraconazole has no meaningful interaction with tramadol in subjects who have functional CYP2D6 enzyme.