A1 Refereed original research article in a scientific journal
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits
Authors: Hottenga J., Iorio A., Kors J., Linneberg A., Ford I., Hansen T., Harris T., Heckbert S., Silva Aldana C., Sinagra G., Sinner M., Soliman E., MacFarlane P., Meitinger T., Nelson C., Raitakari O., Gasparini P., Alonso A., Jamshidi Y., Gudnason V., Uitterlinden A., Stoll M., Waldenberger M., van Duijn C., Samani N., Peters A., Ulivi S., Sotoodehnia N., Kanters J., Kääb S., Munroe P., Lehtimäki T., Isaacs A., van der Harst P., de Bakker P., Jukema J., Stricker B., Wilson J., de Geus E., van Setten J., Verweij N., Trompet S., Arking D., Mbarek H., Niemeijer M., Hall L., Grarup N., Gandin I., Brody J., Müller-Nurasyid M., Mei H., Lyytikäinen L., Hemerich D., Warren H., Smith A., Robino A., Prins B., Eijgelsheim M., Caulfield M., Boomsma D., Asselbergs F.
Publisher: Nature Publishing Group
Publication year: 2019
Journal: European Journal of Human Genetics
Journal name in source: European Journal of Human Genetics
Volume: 27
Issue: 6
First page : 952
Last page: 962
Number of pages: 11
ISSN: 1018-4813
DOI: https://doi.org/10.1038/s41431-018-0295-z
Web address : https://www.nature.com/articles/s41431-018-0295-z
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/39536338
Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency < 5%). In addition to many known loci, we identified seven novel locus-trait associations: KCND3, NR3C1, and PLN for PR interval, KCNE1, SGIP1, and NFKB1 for QT interval, and ATP2A2 for QRS duration, of which six were successfully replicated. At these seven loci, we performed conditional analyses and annotated significant SNPs (in exons and regulatory regions), demonstrating involvement of cardiac-related pathways and regulation of nearby genes.
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