Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

: Wurtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, Tiainen M, Perola M, Tillin T, Hughes AD, Mantyselka P, Kahonen M, Lehtimaki T, Sattar N, Hingorani AD, Casas JP, Salomaa V, Kivimaki M, Jarvelin MR, Smith GD, Vanhala M, Lawlor DA, Raitakari OT, Chaturvedi N, Kettunen J, Ala-Korpela M

Publisher: ELSEVIER SCIENCE INC

: 2016

Journal of the American College of Cardiology

: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

: J AM COLL CARDIOL

: 67

: 10

: 1200

: 1210

: 11

: 0735-1097

: 1558-3597

DOI: https://doi.org/10.1016/j.jacc.2015.12.060

CONCLUSIONS Statin use leads to extensive lipid changes beyond LDL-C and appears efficacious for lowering remnant cholesterol. Metabolomic profiling, however, suggested minimal effects on amino acids. The results exemplify how detailed metabolic characterization of genetic proxies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms. (C) 2016 by the American College of Cardiology Foundation.