Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase - UTU Research Portal

A1 Refereed original research article in a scientific journal

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

Authors: Wurtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, Tiainen M, Perola M, Tillin T, Hughes AD, Mantyselka P, Kahonen M, Lehtimaki T, Sattar N, Hingorani AD, Casas JP, Salomaa V, Kivimaki M, Jarvelin MR, Smith GD, Vanhala M, Lawlor DA, Raitakari OT, Chaturvedi N, Kettunen J, Ala-Korpela M

Publisher: ELSEVIER SCIENCE INC

Publication year: 2016

Journal: Journal of the American College of Cardiology

Journal name in source: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Journal acronym: J AM COLL CARDIOL

Volume: 67

Issue: 10

First page : 1200

Last page: 1210

Number of pages: 11

ISSN: 0735-1097

eISSN: 1558-3597

DOI: https://doi.org/10.1016/j.jacc.2015.12.060

Abstract

CONCLUSIONS Statin use leads to extensive lipid changes beyond LDL-C and appears efficacious for lowering remnant cholesterol. Metabolomic profiling, however, suggested minimal effects on amino acids. The results exemplify how detailed metabolic characterization of genetic proxies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms. (C) 2016 by the American College of Cardiology Foundation.