A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Benign proliferative epithelial lesions of oral mucosa are infrequently associated with α‐, β‐, or γ human papillomaviruses
Tekijät: Sirli Kerge, Jessi Vuorinen, Saija Hurme, Tero Soukka, Tarik Gheit, Massimo Tommasino, Stina Syrjänen, Jaana Rautava
Julkaisuvuosi: 2019
Journal: Laryngoscope Investigative Otolaryngology
Vuosikerta: 4
Numero: 1
Aloitussivu: 43
Lopetussivu: 48
Sivujen määrä: 6
ISSN: 2378-8038
DOI: https://doi.org/10.1002/lio2.222
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/39401653
Background
Oral papillomas and verruca vulgaris have been associated with human papillomavirus (HPV) infection. However, approximately half of these have remained HPV‐negative when tested for mucosal HPV genotypes. In this study, we evaluated presence of α‐, β‐, and γ‐HPVs in benign papillary and verrucous lesions.
MethodsEighty‐three clinical lesions with suspected HPV etiology were analyzed for HPV types of genus α (n = 24), β (n = 46), and γ (n = 52). Immunohistochemistry was used for p16 as a possible surrogate marker of high‐risk HPV, accompanied by Ki‐67 proliferation marker.
ResultsAltogether, α‐HPVs were detected in 6.4%, β‐HPVs in 2.4%, and γ‐HPV in 4.8%. The following genotypes were identified: HPV6, 8, 11, 16, 22, 161, and 170. Neither Ki‐67 nor p16 positivity alone were associated with HPV but combined staining showed significant inverse association (P = .042).
ConclusionHPV infection is found only in a minority of benign verrucous and papillary oral lesions, with the predominance of α‐HPVs.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
