Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice

: Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Warri A, Grunau S, Antonenkov VD, Hiltunen JK

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

: 2014

: Developmental Biology

: DEVELOPMENTAL BIOLOGY

: DEV BIOL

: 391

: 1

: 66

: 80

: 15

: 0012-1606

: 1095-564X

DOI: https://doi.org/10.1016/j.ydbio.2014.03.022

The results point to disturbances of lipid metabolism in the mammary fat pad that in turn may result in abnormal epithelial growth. The work reveals impaired mammary gland development as a new category of peroxisomal disorders. (C) 2014 Elsevier Inc. All rights reserved.