A1 Refereed original research article in a scientific journal

Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol



Authors: Laurila PP, Surakka I, Sarin AP, Yetukuri L, Hyotylainen T, Soderlund S, Naukkarinen J, Tang J, Kettunen J, Mirel DB, Soronen J, Lehtimaki T, Ruokonen A, Ehnholm C, Eriksson JG, Salomaa V, Jula A, Raitakari OT, Jarvelin MR, Palotie A, Peltonen L, Oresic M, Jauhiainen M, Taskinen MR, Ripatti S

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2013

Journal: Arteriosclerosis, Thrombosis, and Vascular Biology

Journal name in source: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Journal acronym: ARTERIOSCL THROM VAS

Volume: 33

Issue: 4

First page : 847

Last page: 857

Number of pages: 39

ISSN: 1079-5642

DOI: https://doi.org/10.1161/ATVBAHA.112.300733


Abstract
Conclusions-Our study highlights the role of inflammation with a genetic component in subjects with low HDL-C and identifies novel cis-expression quantitative trait loci (cis-eQTL) variants in HLA region to be associated with low HDL-C. (Arterioscler Thromb Vasc Biol. 2013;33:847-857.)


Research Areas



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