A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Structural and functional abnormalities of left-sided cardiac chambers in Barlow's disease without significant mitral regurgitation




TekijätMeucci, Maria Chiara; Mantegazza, Valentina; Wu, Hoi W.; van Wijngaarden, Aniek L.; Garlaschè, Anna; Tamborini, Gloria; Pepi, Mauro; Bax, Jeroen J.; Ajmone Marsan, Nina

KustantajaOxford University Press

Julkaisuvuosi2024

JournalEHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging

Tietokannassa oleva lehden nimiEuropean heart journal. Cardiovascular Imaging

Lehden akronyymiEur Heart J Cardiovasc Imaging

Vuosikerta25

Numero9

Aloitussivu1296

Lopetussivu1305

ISSN2047-2404

eISSN2047-2412

DOIhttps://doi.org/10.1093/ehjci/jeae121

Verkko-osoitehttps://academic.oup.com/ehjcimaging/advance-article/doi/10.1093/ehjci/jeae121/7665228?searchresult=1

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/393473970


Tiivistelmä

Aims

To explore the presence of left ventricular (LV) and left atrial (LA) morphological and functional abnormalities in patients with Barlow's disease (BD) without significant mitral regurgitation (MR) and to investigate whether these abnormalities may predict MR progression.

Methods and results

Consecutive patients with BD were retrospectively identified from two tertiary centers; those with MR graded from trivial to mild-to-moderate were selected and matched with healthy controls in a 1:1 ratio. Conventional and speckle-tracking echocardiographic data were collected. The development of moderate-to-severe or greater MR was evaluated on follow-up echocardiograms.Patients with BD (n=231) showed increased LV dimensions and indexed LV mass (LVMi) in comparison to controls (p<0.001); LV remodeling worsened with higher MR severity and was accompanied by an increased prevalence of eccentric LV hypertrophy (eLVH). Moreover, BD patients had larger LA volumes and more impaired LA reservoir strain versus controls (p<0.001), while LV strain was similar between the two groups. Multivariable linear regression analyses in the overall population identified BD and MR grade as independent predictors of remodeling markers (LV dimensions, LVMi and LA volume), and BD as independent correlate of LA strain.MR progression was observed in 51 BD subjects (out of 170 patients with available follow-up). On Cox regression analysis, age, eLVH, mild-to-moderate MR and mitral annular disjunction (MAD) emerged as independent predictors of MR progression.

Conclusions

BD patients without significant MR show early LV and LA remodeling, together with reduced LA strain. MR progression was associated with eccentric LV remodeling, MAD, and MR severity.


Ladattava julkaisu

This is an electronic reprint of the original article.
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Julkaisussa olevat rahoitustiedot
None declared.


Last updated on 2025-06-05 at 09:39