A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Structural and functional abnormalities of left-sided cardiac chambers in Barlow's disease without significant mitral regurgitation
Tekijät: Meucci, Maria Chiara; Mantegazza, Valentina; Wu, Hoi W.; van Wijngaarden, Aniek L.; Garlaschè, Anna; Tamborini, Gloria; Pepi, Mauro; Bax, Jeroen J.; Ajmone Marsan, Nina
Kustantaja: Oxford University Press
Julkaisuvuosi: 2024
Journal: EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Tietokannassa oleva lehden nimi: European heart journal. Cardiovascular Imaging
Lehden akronyymi: Eur Heart J Cardiovasc Imaging
Vuosikerta: 25
Numero: 9
Aloitussivu: 1296
Lopetussivu: 1305
ISSN: 2047-2404
eISSN: 2047-2412
DOI: https://doi.org/10.1093/ehjci/jeae121
Verkko-osoite: https://academic.oup.com/ehjcimaging/advance-article/doi/10.1093/ehjci/jeae121/7665228?searchresult=1
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/393473970
Aims
To explore the presence of left ventricular (LV) and left atrial (LA) morphological and functional abnormalities in patients with Barlow's disease (BD) without significant mitral regurgitation (MR) and to investigate whether these abnormalities may predict MR progression.
Methods and results
Consecutive patients with BD were retrospectively identified from two tertiary centers; those with MR graded from trivial to mild-to-moderate were selected and matched with healthy controls in a 1:1 ratio. Conventional and speckle-tracking echocardiographic data were collected. The development of moderate-to-severe or greater MR was evaluated on follow-up echocardiograms.Patients with BD (n=231) showed increased LV dimensions and indexed LV mass (LVMi) in comparison to controls (p<0.001); LV remodeling worsened with higher MR severity and was accompanied by an increased prevalence of eccentric LV hypertrophy (eLVH). Moreover, BD patients had larger LA volumes and more impaired LA reservoir strain versus controls (p<0.001), while LV strain was similar between the two groups. Multivariable linear regression analyses in the overall population identified BD and MR grade as independent predictors of remodeling markers (LV dimensions, LVMi and LA volume), and BD as independent correlate of LA strain.MR progression was observed in 51 BD subjects (out of 170 patients with available follow-up). On Cox regression analysis, age, eLVH, mild-to-moderate MR and mitral annular disjunction (MAD) emerged as independent predictors of MR progression.
Conclusions
BD patients without significant MR show early LV and LA remodeling, together with reduced LA strain. MR progression was associated with eccentric LV remodeling, MAD, and MR severity.
Ladattava julkaisu This is an electronic reprint of the original article. |
Julkaisussa olevat rahoitustiedot:
None declared.