Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures : an exploratory study
: Bekkering, Siroon; Saner, Christoph; Novakovic, Boris; Mansell, Toby; Longmore, Danielle K.; McCallum, Zoe; Ponsonby, Anne-Louise; Juonala, Markus; Netea, Mihai G.; Sabin, Matthew A.; Saffery, Richard; Riksen, Niels P.; Burgner, David P.
Publisher: Cell Press
: 2024
iScience
: iScience
: 109762
: 27
: 5
: 2589-0042
: 2589-0042
DOI: https://doi.org/10.1016/j.isci.2024.109762
: https://doi.org/10.1016/j.isci.2024.109762
: https://research.utu.fi/converis/portal/detail/Publication/393367653
Cardiometabolic risk accrues across the lifecourse and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but paediatric data are scarce. In a cross-sectional and longitudinal study, we investigated immune cell composition and activation in 31 adolescents with obesity (41.9% male, BMIz>2.5, 14.4y) and 22 controls with healthy weight (45.1% male, -1.5
