Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures : an exploratory study

: Bekkering Siroon, Saner Christoph, Novakovic Boris, Mansell Toby, Longmore Danielle K., McCallum Zoe, Ponsonby Anne-Louise, Juonala Markus, Netea Mihai G., Sabin Matthew A., Saffery Richard, Riksen Niels P., Burgner David P.

Publisher: Cell Press

: 2024

: iScience

: 109762

: 27

: 5

: 2589-0042

DOI: https://doi.org/10.1016/j.isci.2024.109762

: https://doi.org/10.1016/j.isci.2024.109762

: https://research.utu.fi/converis/portal/detail/Publication/393367653

Cardiometabolic risk accrues across the lifecourse and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but paediatric data are scarce. In a cross-sectional and longitudinal study, we investigated immune cell composition and activation in 31 adolescents with obesity (41.9% male, BMIz>2.5, 14.4y) and 22 controls with healthy weight (45.1% male, -1.5

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