B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Base moiety selectivity in cleavage of short oligonucleotides by di- and trinuclear Zn(II) complexes of azacrown-derived ligands
Tekijät: Ketomaki K, Paivi-Poijarvi-Virta, Wang Q, Lonnberg H
Julkaisuvuosi: 2008
Lehti: Collection Symposium Series
Tietokannassa oleva lehden nimi: CHEMISTRY OF NUCLEIC ACID COMPONENTS
Lehden akronyymi: COLL SYMPOS SERIES
Vuosikerta: 10
Aloitussivu: 437
Lopetussivu: 438
Sivujen määrä: 2
ISBN: 978-80-86241-29-6
Tiivistelmä
Cleavage of short oligoribonucleotides by a dinuclear Zn(2+) complex of 1,4-bis[(1,5,9-triazacyclododecan-3-yl)oxy methyl] benzene (L(1)) and trinuclear Zn(2+) complex of 1,3,5-tris[(1,5,9-triazacyclododecan-3-yl)oxymethyl] benzene (L(2)) has been studied. Zn(2+)L(1) at sufficiently low concentrations (< 0.1 mmol L(-1)) cleaves NpU and/or UpN bonds (N = G, C, A) much more readily than the other phosphodiester bonds. UpU sites, however, remain intact. Zn(2+)L(2), in turn, cleaves UpU bonds more readily than any other linkages, even more readily than NpU and UpN sites. This cleaving agent shows considerable cleaving activity also towards GpG sites.
Cleavage of short oligoribonucleotides by a dinuclear Zn(2+) complex of 1,4-bis[(1,5,9-triazacyclododecan-3-yl)oxy methyl] benzene (L(1)) and trinuclear Zn(2+) complex of 1,3,5-tris[(1,5,9-triazacyclododecan-3-yl)oxymethyl] benzene (L(2)) has been studied. Zn(2+)L(1) at sufficiently low concentrations (< 0.1 mmol L(-1)) cleaves NpU and/or UpN bonds (N = G, C, A) much more readily than the other phosphodiester bonds. UpU sites, however, remain intact. Zn(2+)L(2), in turn, cleaves UpU bonds more readily than any other linkages, even more readily than NpU and UpN sites. This cleaving agent shows considerable cleaving activity also towards GpG sites.
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