Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats



: Linderborg Kaisa M., Kulkarni Amruta, Zhao Ai, Zhang Jian, Kallio Heikki, Magnusson Johann D., Haraldsson Gudmundur G., Zhang Yumei, Yang Baoru

: 2019

: Food Chemistry

: Food chemistry

: Food Chem

: 283

: 381

: 389

: 9

: 0308-8146

: 1873-7072

DOI: https://doi.org/10.1016/j.foodchem.2018.12.130

: https://research.utu.fi/converis/portal/detail/Publication/39151018


Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.

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