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Reduced Striatal Dopamine Synthesis Capacity is Associated with Symptoms of Depression in Patients with de novo Unmedicated Parkinson's Disease
Tekijät: Joutsa J, Rinne JO, Eskola O, Kaasinen V
Kustantaja: IOS Press
Julkaisuvuosi: 2013
Journal: Journal of Parkinson's Disease
Tietokannassa oleva lehden nimi: JOURNAL OF PARKINSONS DISEASE
Lehden akronyymi: J Parkinsons Dis
Numero sarjassa: 3
Vuosikerta: 3
Numero: 3
Aloitussivu: 325
Lopetussivu: 329
Sivujen määrä: 5
ISSN: 1877-7171
eISSN: 1877-718X
DOI: https://doi.org/10.3233/JPD-130205
Tiivistelmä
Previous studies have suggested that impaired striatal dopamine function might be independently related to depression in patients with Parkinson's disease (PD), but the results are not uniform. In this study, we investigated de novo unmedicated and medicated PD patients with more advanced disease using F-18-fluorodopa-PET. In unmedicated de novo patients, but not in medicated patients, higher depression scores were associated with lower striatal F-18-fluorodopa uptake. These results indicate that impaired striatal dopaminergic function in PD is related to depressive symptoms and that these effects can be observed in de novo patients without the confounding effects of advanced neurodegeneration and medications.
Previous studies have suggested that impaired striatal dopamine function might be independently related to depression in patients with Parkinson's disease (PD), but the results are not uniform. In this study, we investigated de novo unmedicated and medicated PD patients with more advanced disease using F-18-fluorodopa-PET. In unmedicated de novo patients, but not in medicated patients, higher depression scores were associated with lower striatal F-18-fluorodopa uptake. These results indicate that impaired striatal dopaminergic function in PD is related to depressive symptoms and that these effects can be observed in de novo patients without the confounding effects of advanced neurodegeneration and medications.
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