A1 Refereed original research article in a scientific journal
Reduced Striatal Dopamine Synthesis Capacity is Associated with Symptoms of Depression in Patients with de novo Unmedicated Parkinson's Disease
Authors: Joutsa J, Rinne JO, Eskola O, Kaasinen V
Publisher: IOS Press
Publication year: 2013
Journal: Journal of Parkinson's Disease
Journal name in source: JOURNAL OF PARKINSONS DISEASE
Journal acronym: J Parkinsons Dis
Number in series: 3
Volume: 3
Issue: 3
First page : 325
Last page: 329
Number of pages: 5
ISSN: 1877-7171
eISSN: 1877-718X
DOI: https://doi.org/10.3233/JPD-130205
Abstract
Previous studies have suggested that impaired striatal dopamine function might be independently related to depression in patients with Parkinson's disease (PD), but the results are not uniform. In this study, we investigated de novo unmedicated and medicated PD patients with more advanced disease using F-18-fluorodopa-PET. In unmedicated de novo patients, but not in medicated patients, higher depression scores were associated with lower striatal F-18-fluorodopa uptake. These results indicate that impaired striatal dopaminergic function in PD is related to depressive symptoms and that these effects can be observed in de novo patients without the confounding effects of advanced neurodegeneration and medications.
Previous studies have suggested that impaired striatal dopamine function might be independently related to depression in patients with Parkinson's disease (PD), but the results are not uniform. In this study, we investigated de novo unmedicated and medicated PD patients with more advanced disease using F-18-fluorodopa-PET. In unmedicated de novo patients, but not in medicated patients, higher depression scores were associated with lower striatal F-18-fluorodopa uptake. These results indicate that impaired striatal dopaminergic function in PD is related to depressive symptoms and that these effects can be observed in de novo patients without the confounding effects of advanced neurodegeneration and medications.
UTU Research Portal