Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles

: Pereira Sarah A.P., Passos Marieta L.C., Correia Alexandra, Mäkilä Ermei, Salonen Jarno, Araujo André R.S.T., Santos Hélder A., Saraiva M. Lúcia M. .S.

: 2019

: Talanta

: 196

: 277

: 283

: 7

: 0039-9140

: 1873-3573

DOI: https://doi.org/10.1016/j.talanta.2018.12.025

The drug loading and release procedures were optimized in sequential injection analysis (SIA) systems obtaining a huge economy regarding the time spent (4 min towards 2 h). Batch and SIA methods were tested and compared for the different behaviours of the PSi nanoparticles towards both methodologies and no noteworthy differences were obtained with Student's t-test for loading with a calculated t value of 2.04 showing the absence of statistical differences. All the results present a RSD less than 10%. So, the developed automatic methodologies are a viable alternative to load drugs and to study the release profiles from PSi nanoparticles.