A1 Refereed original research article in a scientific journal

Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles




AuthorsPereira Sarah A.P., Passos Marieta L.C., Correia Alexandra, Mäkilä Ermei, Salonen Jarno, Araujo André R.S.T., Santos Hélder A., Saraiva M. Lúcia M. .S.

Publication year2019

JournalTalanta

Journal name in sourceTalanta

Journal acronymTalanta

Volume196

First page 277

Last page283

Number of pages7

ISSN0039-9140

eISSN1873-3573

DOIhttps://doi.org/10.1016/j.talanta.2018.12.025


Abstract
The drug loading and release procedures were optimized in sequential injection analysis (SIA) systems obtaining a huge economy regarding the time spent (4 min towards 2 h). Batch and SIA methods were tested and compared for the different behaviours of the PSi nanoparticles towards both methodologies and no noteworthy differences were obtained with Student's t-test for loading with a calculated t value of 2.04 showing the absence of statistical differences. All the results present a RSD less than 10%. So, the developed automatic methodologies are a viable alternative to load drugs and to study the release profiles from PSi nanoparticles.



Last updated on 2024-26-11 at 11:41