A1 Refereed original research article in a scientific journal
Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles
Authors: Pereira Sarah A.P., Passos Marieta L.C., Correia Alexandra, Mäkilä Ermei, Salonen Jarno, Araujo André R.S.T., Santos Hélder A., Saraiva M. Lúcia M. .S.
Publication year: 2019
Journal: Talanta
Journal name in source: Talanta
Journal acronym: Talanta
Volume: 196
First page : 277
Last page: 283
Number of pages: 7
ISSN: 0039-9140
eISSN: 1873-3573
DOI: https://doi.org/10.1016/j.talanta.2018.12.025
Abstract
The drug loading and release procedures were optimized in sequential injection analysis (SIA) systems obtaining a huge economy regarding the time spent (4 min towards 2 h). Batch and SIA methods were tested and compared for the different behaviours of the PSi nanoparticles towards both methodologies and no noteworthy differences were obtained with Student's t-test for loading with a calculated t value of 2.04 showing the absence of statistical differences. All the results present a RSD less than 10%. So, the developed automatic methodologies are a viable alternative to load drugs and to study the release profiles from PSi nanoparticles.
The drug loading and release procedures were optimized in sequential injection analysis (SIA) systems obtaining a huge economy regarding the time spent (4 min towards 2 h). Batch and SIA methods were tested and compared for the different behaviours of the PSi nanoparticles towards both methodologies and no noteworthy differences were obtained with Student's t-test for loading with a calculated t value of 2.04 showing the absence of statistical differences. All the results present a RSD less than 10%. So, the developed automatic methodologies are a viable alternative to load drugs and to study the release profiles from PSi nanoparticles.
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