B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
On-support oximation: A convenient method for solid-supported conjugation of oligonucleotides
Tekijät: Virta P, Katajisto J, Lonnberg H
Julkaisuvuosi: 2005
Lehti:: Collection Symposium Series
Tietokannassa oleva lehden nimi: Chemistry of Nucleic Acid Components
Lehden akronyymi: COLL SYMPOS SERIES
Vuosikerta: 7
Aloitussivu: 265
Lopetussivu: 267
Sivujen määrä: 3
ISBN: 80-86241-25-4
Tiivistelmä
Oximation (i.e. reaction between an aminooxy and an aldehyde group) has been shown to be an attractive coupling method for on-support conjugation of oligonucleotides. For that purpose, base tethered (1) and two normucleosidic (2 and 3) phosphoramidites, bearing phthaloyl protected aminooxy groups have been prepared and their applicability to solidphase oligonucleotide assembly and on-support conjugation with various aldehydes have been demonstrated.
Oximation (i.e. reaction between an aminooxy and an aldehyde group) has been shown to be an attractive coupling method for on-support conjugation of oligonucleotides. For that purpose, base tethered (1) and two normucleosidic (2 and 3) phosphoramidites, bearing phthaloyl protected aminooxy groups have been prepared and their applicability to solidphase oligonucleotide assembly and on-support conjugation with various aldehydes have been demonstrated.
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