B1 Non-refereed article in a scientific journal
On-support oximation: A convenient method for solid-supported conjugation of oligonucleotides
Authors: Virta P, Katajisto J, Lonnberg H
Publication year: 2005
Journal:: Collection Symposium Series
Journal name in source: Chemistry of Nucleic Acid Components
Journal acronym: COLL SYMPOS SERIES
Volume: 7
First page : 265
Last page: 267
Number of pages: 3
ISBN: 80-86241-25-4
Abstract
Oximation (i.e. reaction between an aminooxy and an aldehyde group) has been shown to be an attractive coupling method for on-support conjugation of oligonucleotides. For that purpose, base tethered (1) and two normucleosidic (2 and 3) phosphoramidites, bearing phthaloyl protected aminooxy groups have been prepared and their applicability to solidphase oligonucleotide assembly and on-support conjugation with various aldehydes have been demonstrated.
Oximation (i.e. reaction between an aminooxy and an aldehyde group) has been shown to be an attractive coupling method for on-support conjugation of oligonucleotides. For that purpose, base tethered (1) and two normucleosidic (2 and 3) phosphoramidites, bearing phthaloyl protected aminooxy groups have been prepared and their applicability to solidphase oligonucleotide assembly and on-support conjugation with various aldehydes have been demonstrated.
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