alpha(2A)-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice



: Fagerholm V, Scheinin M, Haaparanta M

Publisher: WILEY-BLACKWELL

: 2008

British Journal of Pharmacology

BRITISH JOURNAL OF PHARMACOLOGY

: BRIT J PHARMACOL

: 154

: 6

: 1287

: 1296

: 10

: 0007-1188

DOI: https://doi.org/10.1038/bjp.2008.186


Conclusions and implications: These results suggest that (+/-)-efaroxan and phentolamine increase insulin secretion by inhibition of beta-cell alpha(2A)-adrenoceptors, and demonstrate a critical role for alpha(2A)-adrenoceptors in limiting sulphonylurea-induced hyperinsulinaemia and hypoglycaemia.




Last updated on 2025-14-10 at 10:09