alpha(2A)-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice - UTU Research Portal

A1 Refereed original research article in a scientific journal

alpha(2A)-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice

Authors: Fagerholm V, Scheinin M, Haaparanta M

Publisher: WILEY-BLACKWELL

Publication year: 2008

Journal:: British Journal of Pharmacology

Journal name in source: BRITISH JOURNAL OF PHARMACOLOGY

Journal acronym: BRIT J PHARMACOL

Volume: 154

Issue: 6

First page : 1287

Last page: 1296

Number of pages: 10

ISSN: 0007-1188

DOI: https://doi.org/10.1038/bjp.2008.186

Abstract

Conclusions and implications: These results suggest that (+/-)-efaroxan and phentolamine increase insulin secretion by inhibition of beta-cell alpha(2A)-adrenoceptors, and demonstrate a critical role for alpha(2A)-adrenoceptors in limiting sulphonylurea-induced hyperinsulinaemia and hypoglycaemia.