A1 Refereed original research article in a scientific journal

Radiotherapy volume delineation using dynamic [18F]-FDG PET/CT imaging in patients with oropharyngeal cancer: a pilot study




AuthorsSilvoniemi A, Din MU, Suilamo S, Shepherd T, Minn H

PublisherSpringer Berlin Heidelberg

Publication year2016

JournalInternational journal of computer assisted radiology and surgery

Journal acronymInt J Comput Assist Radiol Surg

Volume11

Issue11

First page 2059

Last page2069

Number of pages11

ISSN1861-6410

eISSN1861-6429

DOIhttps://doi.org/10.1007/s11548-016-1351-1

Web address http://download.springer.com/static/pdf/42/art:10.1007/s11548-016-1351-1.pdf?originUrl=http://link.springer.com/article/10.1007/s11548-016-1351-1&token2=exp=1455713021~acl=/static/pdf/42/art:10.1007/s11548-016-1351-1.pdf?originUrl=http://link.springer.com/article/10.1007/s11548-016-1351-1*~hmac=25f1b22cc029ea03886e7f4994d50f7d5e298a1f75e3cc58a95164186d187e65


Abstract

Abstract


PURPOSE:

Delineation of gross tumour volume in 3D is a critical step in the radiotherapy (RT) treatment planning for oropharyngeal cancer (OPC). Static [Formula: see text]-FDG PET/CT imaging has been suggested as a method to improve the reproducibility of tumour delineation, but it suffers from low specificity. We undertook this pilot study in which dynamic features in time-activity curves (TACs) of [Formula: see text]-FDG PET/CT images were applied to help the discrimination of tumour from inflammation and adjacent normal tissue.



METHODS:

Five patients with OPC underwent dynamic [Formula: see text]-FDG PET/CT imaging in treatment position. Voxel-by-voxel analysis was performed to evaluate seven dynamic features developed with the knowledge of differences in glucose metabolism in different tissue types and visual inspection of TACs. The Gaussian mixture model and K-means algorithms were used to evaluate the performance of the dynamic features in discriminating tumour voxels compared to the performance of standardized uptake values obtained from static imaging.



RESULTS:

Some dynamic features showed a trend towards discrimination of different metabolic areas but lack of consistency means that clinical application is not recommended based on these results alone.



CONCLUSIONS:

Impact of inflammatory tissue remains a problem for volume delineation in RT of OPC, but a simple dynamic imaging protocol proved practicable and enabled simple data analysis techniques that show promise for complementing the information in static uptake values.



 


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.





Last updated on 2024-26-11 at 22:22