A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Use of the Phylobone database for the annotation of bone extracellular matrix proteins in reindeer (Rangifer tarandus)
Tekijät: Sánchez-Reverté Alba, Fontcuberta-Rigo Margalida, Nakamura Miho, Puigbò Pere
Kustantaja: Sage
Julkaisuvuosi: 2024
Journal: Science Progress
Tietokannassa oleva lehden nimi: Science progress
Lehden akronyymi: Sci Prog
Vuosikerta: 107
Numero: 2
ISSN: 0036-8504
eISSN: 2047-7163
DOI: https://doi.org/10.1177/00368504241244666
Verkko-osoite: https://journals.sagepub.com/doi/10.1177/00368504241244666
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387677281
Bone extracellular matrix (ECM) proteins play a key role in bone formation and regeneration, including structural and regulatory functions. The Phylobone database consists of 255 ECM protein groups from 39 species and can be used to support bone research. Here, we gathered bone ECM proteins from reindeer (Rangifer tarandus), a member of the Cervidae family. The importance of reindeer lies in their ability to regenerate their antlers, in both male and female individuals. Protein sequences were extracted from the National Center for Biotechnology Information's repository and selected by homology searches. We identified 215 proteins and their corresponding functional domains, which are putatively present in the bone ECM of reindeer. Protein sequence alignments have shown a high degree of conservation between R. tarandus and other members of the Cervidae family. This update expands the Phylobone database and shows that it is a useful resource for the preliminary annotation of bone ECM proteins in novel proteomes.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
