A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)
Tekijät: Jalo Anna, Helin Jatta S, Hentilä Jaakko, Nissinen Tuuli A, Honkala Sanna M, Heiskanen Marja A, Löyttyniemi Eliisa, Malm Tarja, Hannukainen Jarna C
Kustantaja: MPDI
Julkaisuvuosi: 2024
Journal: Journal of Functional Morphology and Kinesiology
Tietokannassa oleva lehden nimi: Journal of Functional Morphology and Kinesiology
Artikkelin numero: 58
Vuosikerta: 9
Numero: 2
ISSN: 2411-5142
eISSN: 2411-5142
DOI: https://doi.org/10.3390/jfmk9020058
Verkko-osoite: https://www.mdpi.com/2411-5142/9/2/58
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387461751
Recent studies have shown that obesity and insulin resistance are associated with increased insulin-stimulated glucose uptake (GU) in the brain. Thus, insulin sensitivity seems to work differently in the brain compared to the peripheral tissues like skeletal muscles, but the underlying mechanisms remain unknown. Regular exercise training improves skeletal muscle and whole-body insulin sensitivity. However, the effect of exercise on glucose metabolism in the brain and internal organs is less well understood. The CROSRAT study aims to investigate the effects of exercise training on brain glucose metabolism and inflammation in a high-fat diet-induced rat model of obesity and insulin resistance. Male Sprague Dawley rats (n = 144) are divided into nine study groups that undergo different dietary and/or exercise training interventions lasting 12 to 24 weeks. Insulin-stimulated GU from various tissues and brain inflammation are investigated using [18F]FDG-PET/CT and [11C]PK11195-PET/CT, respectively. In addition, peripheral tissue, brain, and fecal samples are collected to study the underlying mechanisms. The strength of this study design is that it allows examining the effects of both diet and exercise training on obesity-induced insulin resistance and inflammation. As the pathophysiological changes are studied simultaneously in many tissues and organs at several time points, the study provides insight into when and where these pathophysiological changes occur.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
