A1 Refereed original research article in a scientific journal
Surface modification of additive manufactured Ti6Al4V scaffolds with gelatin/alginate- IGF-1 carrier : An effective approach for healing bone defects
Authors: Mofazali Parinaz, Atapour Masoud, Nakamura Miho, Sheikholeslam Mohammadali, Galati Manuela, Saboori Abdollah
Publisher: Elsevier
Publication year: 2024
Journal: International Journal of Biological Macromolecules
Journal name in source: International journal of biological macromolecules
Journal acronym: Int J Biol Macromol
Article number: 131125
Volume: 265
Issue: Part 2
ISSN: 0141-8130
eISSN: 1879-0003
DOI: https://doi.org/10.1016/j.ijbiomac.2024.131125
Web address : https://doi.org/10.1016/j.ijbiomac.2024.131125
Abstract
The study investigates the potential of porous scaffolds with Gel/Alg-IGF-1 coatings as a viable candidate for orthopaedic implants. The scaffolds are composed of additively manufactured Ti6Al4V lattices, which were treated in an alkali solution to obtain the anatase and rutile phases. The treated surface exhibited hydrophilicity of <11.5°. A biopolymer carrier containing Insulin-like growth factor 1 was coated on the samples using immersion treatment. This study showed that the surface-modified porous Ti6Al4V scaffolds increased cell viability and proliferation, indicating potential for bone regeneration. The results demonstrate that surface modifications can enhance the osteoconduction and osteoinduction of Ti6Al4V implants, leading to improved bone regeneration and faster recovery. The porous Ti6Al4V scaffolds modified with surface coating of Gel/Alg-IGF-1 exhibited a noteworthy increase in cell viability (from 80.7 to 104.1%viability) and proliferation. These results suggest that the surface modified scaffolds have potential for use in treating bone defects.
The study investigates the potential of porous scaffolds with Gel/Alg-IGF-1 coatings as a viable candidate for orthopaedic implants. The scaffolds are composed of additively manufactured Ti6Al4V lattices, which were treated in an alkali solution to obtain the anatase and rutile phases. The treated surface exhibited hydrophilicity of <11.5°. A biopolymer carrier containing Insulin-like growth factor 1 was coated on the samples using immersion treatment. This study showed that the surface-modified porous Ti6Al4V scaffolds increased cell viability and proliferation, indicating potential for bone regeneration. The results demonstrate that surface modifications can enhance the osteoconduction and osteoinduction of Ti6Al4V implants, leading to improved bone regeneration and faster recovery. The porous Ti6Al4V scaffolds modified with surface coating of Gel/Alg-IGF-1 exhibited a noteworthy increase in cell viability (from 80.7 to 104.1%viability) and proliferation. These results suggest that the surface modified scaffolds have potential for use in treating bone defects.
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