A1 Refereed original research article in a scientific journal
Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment
Authors: França Lucas G. S., Ciarrusta Judit, Gale-Grant Oliver, Fenn-Moltu Sunniva, Fitzgibbon Sean, Chew Andrew, Falconer Shona, Dimitrova Ralica, Cordero-Grande Lucilio, Price Anthony N., Hughes Emer, O’Muircheartaigh Jonathan, Duff Eugene, Tuulari Jetro J., Deco Gustavo, Counsell Serena J., Hajnal Joseph V., Nosarti Chiara, Arichi Tomoki, Edwards A. David, McAlonan Grainne, Batalle Dafnis
Publisher: Springer Nature
Publication year: 2024
Journal: Nature Communications
Journal name in source: Nature Communications
Article number: 16
Volume: 15
Issue: 1
eISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-023-44050-z
Web address : https://www.nature.com/articles/s41467-023-44050-z
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387306103
Brain dynamic functional connectivity characterises transient connections between brain regions. Features of brain dynamics have been linked to emotion and cognition in adult individuals, and atypical patterns have been associated with neurodevelopmental conditions such as autism. Although reliable functional brain networks have been consistently identified in neonates, little is known about the early development of dynamic functional connectivity. In this study we characterise dynamic functional connectivity with functional magnetic resonance imaging (fMRI) in the first few weeks of postnatal life in term-born (n = 324) and preterm-born (n = 66) individuals. We show that a dynamic landscape of brain connectivity is already established by the time of birth in the human brain, characterised by six transient states of neonatal functional connectivity with changing dynamics through the neonatal period. The pattern of dynamic connectivity is atypical in preterm-born infants, and associated with atypical social, sensory, and repetitive behaviours measured by the Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores at 18 months of age. © The Author(s) 2024.
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