Multifactorial prevention program for cardiovascular disease in primary care: hypertension status and effect on mortality




Kuneinen Susanna M., Kautiainen Hannu, Ekblad Mikael O., Korhonen Päivi E.

PublisherSpringer Nature

2024

Journal of Human Hypertension

Journal of Human Hypertension

38

332

328

1476-5527

DOIhttps://doi.org/10.1038/s41371-024-00900-x(external)

https://www.nature.com/articles/s41371-024-00900-x(external)

https://research.utu.fi/converis/portal/detail/Publication/387289578(external)



The aim of this study was to investigate if mortality during a 13-year follow-up varied between normotensive subjects, screen-detected hypertensive subjects, and subjects with antihypertensive medication at baseline. A population-based screening and intervention program identified 2659 apparently healthy, middle-aged cardiovascular-risk persons in southwestern Finland. Screen-detected hypertension was verified by home blood pressure measurements. Lifestyle counseling was provided for all participants and preventive medications were started or intensified if needed. All-cause and cardiovascular mortality were obtained from the official statistics. Screen-detected hypertension was diagnosed in 17% of the participants, 51% were normotensive and 32% had antihypertensive medication at baseline. The screen-detected hypertensives had higher mean blood pressure and cholesterol levels than the two other groups. Altogether 289 subjects died during the follow-up, 83 (29%) from cardiovascular disease. Those with screen-detected hypertension had decreased cardiovascular mortality risk compared to the medicated hypertensives [sHR 0.40 (95% CI: 0.19 to 0.88, p = 0.023)], and comparable with that of the normotensives [sHR 0.53 (95% CI: 0.24 to 1.15)]. Newly diagnosed diabetes at baseline was a powerful predictor of cardiovascular mortality [sHR 2.71 (95% CI: 1.57 to 4.69)]. Early detection of hypertension and timely multifactorial intervention seem to be important in preventing hypertension-related mortality. © The Author(s) 2024.

Last updated on 2024-26-11 at 15:44