A2 Refereed review article in a scientific journal
Engineering and Targeting Neutrophils for Cancer Therapy
Authors: Zhang Jiahui, Gu Jianmei, Wang Xu, Ji Cheng, Yu Dan, Wan Maoye, Pan Jianming, Santo Helder A., Zhang Hongbo, Zhang Xu
Publisher: WILEY-V C H VERLAG GMBH
Publishing place: WEINHEIM
Publication year: 2024
Journal: Advanced Materials
Journal name in source: ADVANCED MATERIALS
Journal acronym: ADV MATER
Article number: 2310318
Volume: 36
Issue: 19
Number of pages: 34
ISSN: 0935-9648
eISSN: 1521-4095
DOI: https://doi.org/10.1002/adma.202310318
Web address : https://doi.org/10.1002/adma.202310318
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387262940
Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti-tumor properties while N2 neutrophils display tumor-supportive and immune-suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re-polarization of tumor-promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation-responsive and physical barrier-crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.This review summarizes the recent advances in engineering neutrophils and their derivatives as drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. Targeting neutrophils for remodeling tumor microenvironment (TME) and reinvigorating anti-tumor immunity provide a broad understanding of the potential application of neutrophils in cancer therapy. image
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