A1 Refereed original research article in a scientific journal
Pine-Oil-Derived Sodium Resinate Inhibits Growth and Acid Production of Streptococcus mutans In Vitro
Authors: Rajala Otto, Mäntynen Matias, Loimaranta Vuokko
Publisher: MDPI
Publication year: 2024
Journal: Dentistry Journal
Journal name in source: DENTISTRY JOURNAL
Journal acronym: DENT J-BASEL
Article number: 40
Volume: 12
Issue: 2
Number of pages: 11
eISSN: 2304-6767
DOI: https://doi.org/10.3390/dj12020040
Web address : https://www.mdpi.com/2304-6767/12/2/40
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387235805
S. mutans is a key pathogen in dental caries initiation and progression. It promotes oral biofilm dysbiosis and biofilm acidification. Sodium resinate is a salt of pine-oil-derived resin which has antimicrobial properties. Pine-oil-derived resin consists of terpenes, diterpenes, and abietic acids. The aim of this study was to determine the effects of pine (Pinus sylvestris) oil resinate (RS) on growth and acid production of cariogenic S. mutans strains in planktonic form and biofilm. The S. mutans type strain NCTC10449 and clinical isolate CI2366 were grown on 96-well plates for testing of RS effects on growth and biofilm formation, and on plates with integrated pH-sensitive optical ensors for real-time measurements of the effects of RS on bacterial acid production. We found that even short-time exposure to RS inhibits the growth and acid production of S. mutans in the planktonic phase and biofilms. In addition, RS was able to penetrate the biofilm matrix and reduce acid production inside S. mutans biofilm. RS thus shows potential as a novel antibacterial agent against cariogenic bacteria in biofilm.
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