A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma
Tekijät: Almangush Alhadi, Hagström Jaana, Haglund Caj, Kowalski Luiz Paulo, Coletta Ricardo D., Mäkitie Antti A., Salo Tuula, Leivo Ilmo
Kustantaja: BioMed Central
Julkaisuvuosi: 2024
Journal: BMC Cancer
Tietokannassa oleva lehden nimi: BMC CANCER
Lehden akronyymi: BMC CANCER
Artikkelin numero: 213
Vuosikerta: 24
Numero: 1
Sivujen määrä: 8
eISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-024-11954-y
Verkko-osoite: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-11954-y
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387222864
Background: The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).
Methods: We used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.
Results: Single cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).
Conclusion: Single cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
