A1 Refereed original research article in a scientific journal
Predicting antiepileptic drug response in children with epilepsy
Authors: Sillanpää Matti, Schmidt Dieter
Publication year: 2011
Journal: Expert Review of Neurotherapeutics
Number in series: 6
Volume: 11
Issue: 6
First page : 877
Last page: 886
Number of pages: 9
ISSN: 1473-7175
DOI: https://doi.org/10.1586/ERN.11.11
Abstract
In clinical practice, after diagnosis and when treatment has begun, it is important to predict as
soon as possible which children will become seizure-free and which are likely to develop medically
intractable seizures. This article summarizes factors predicting seizure remission in childhoodonset
epilepsy treated with antiepileptic drugs (AEDs). Sustained seizure remission can be
expected in over 90% of idiopathic epilepsies of childhood and in neurologically normal children
with epilepsy having infrequent seizures showing early remission after starting treatment with
AEDs. Even in the presence of symptomatic etiology of epilepsy – focal seizures and syndromes;
high seizure frequency prior to or during treatment; seizure clustering; and poor or delayed
response to first adequate drug therapy – up to 60% of children with treated epilepsy are able
to enter long-term remission. However, remission can be expected in only 30% or less of those
with catastrophic epilepsies of childhood.
In clinical practice, after diagnosis and when treatment has begun, it is important to predict as
soon as possible which children will become seizure-free and which are likely to develop medically
intractable seizures. This article summarizes factors predicting seizure remission in childhoodonset
epilepsy treated with antiepileptic drugs (AEDs). Sustained seizure remission can be
expected in over 90% of idiopathic epilepsies of childhood and in neurologically normal children
with epilepsy having infrequent seizures showing early remission after starting treatment with
AEDs. Even in the presence of symptomatic etiology of epilepsy – focal seizures and syndromes;
high seizure frequency prior to or during treatment; seizure clustering; and poor or delayed
response to first adequate drug therapy – up to 60% of children with treated epilepsy are able
to enter long-term remission. However, remission can be expected in only 30% or less of those
with catastrophic epilepsies of childhood.
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