A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Transcriptional reprogramming at the intersection of the heat shock response and proteostasis
Tekijät: Pessa Jenny C, Joutsen Jenny, Sistonen Lea
Julkaisuvuosi: 2024
Journal: Molecular Cell
Tietokannassa oleva lehden nimi: Molecular cell
Lehden akronyymi: Mol Cell
Vuosikerta: 84
Numero: 1
Aloitussivu: 80
Lopetussivu: 93
ISSN: 1097-2765
eISSN: 1097-4164
DOI: https://doi.org/10.1016/j.molcel.2023.11.024
Verkko-osoite: https://doi.org/10.1016/j.molcel.2023.11.024
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387030268
Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors. To mitigate the stress-induced damage, cells activate transient survival programs. The heat shock response (HSR) is an evolutionarily well-conserved survival program that is activated in response to proteotoxic stress. The HSR encompasses a dual regulation of transcription, characterized by rapid activation of genes encoding molecular chaperones and concomitant global attenuation of non-chaperone genes. Recent genome-wide approaches have delineated the molecular depth of stress-induced transcriptional reprogramming. The dramatic rewiring of gene and enhancer networks is driven by key transcription factors, including heat shock factors (HSFs), that together with chromatin-modifying enzymes remodel the 3D chromatin architecture, determining the selection of either gene activation or repression. Here, we highlight the current advancements of molecular mechanisms driving transcriptional reprogramming during acute heat stress. We also discuss the emerging implications of HSF-mediated stress signaling in the context of physiological and pathological conditions.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
