Interactions of the GnRH receptor with heterotrimeric G proteins

: Naor Zvi, Huhtaniemi Ilpo

: 2013

Frontiers in Neuroendocrinology

: 2

: 34

: 2

: 88

: 94

: 7

: 0091-3022

DOI: https://doi.org/10.1016/j.yfrne.2012.11.001

G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner. (C) 2012 Elsevier Inc. All rights reserved.