A2 Refereed review article in a scientific journal
Interactions of the GnRH receptor with heterotrimeric G proteins
Authors: Naor Zvi, Huhtaniemi Ilpo
Publication year: 2013
Journal: Frontiers in Neuroendocrinology
Number in series: 2
Volume: 34
Issue: 2
First page : 88
Last page: 94
Number of pages: 7
ISSN: 0091-3022
DOI: https://doi.org/10.1016/j.yfrne.2012.11.001
Abstract
G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner. (C) 2012 Elsevier Inc. All rights reserved.
G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner. (C) 2012 Elsevier Inc. All rights reserved.
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