A2 Refereed review article in a scientific journal
Molecular pathology in diagnosis and prognostication of head and neck tumors
Authors: Skálová Alena, Bradová Martina, Michal Michael, Mosaieby Elaheh, Klubíčková Natálie, Vaněček Tomáš, Leivo Ilmo
Publisher: Springer Science and Business Media Deutschland GmbH
Publication year: 2024
Journal: Virchows Archiv
Journal name in source: Virchows Archiv
Volume: 484
Issue: 2
First page : 215
Last page: 231
ISSN: 0945-6317
eISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-023-03731-2
Web address : https://link.springer.com/article/10.1007/s00428-023-03731-2
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/386849265
Classification of head and neck tumors has evolved in recent decades including a widespread application of molecular testing in tumors of the salivary glands, sinonasal tract, oropharynx, nasopharynx, and soft tissue. Availability of new molecular techniques allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, the expanding spectrum of immunohistochemical markers facilitates a rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined classifications, while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review highlights some principal molecular alterations in head and neck neoplasms presently available to assist pathologists in the practice of diagnosis, prognostication and prediction of response to treatment. © 2024, The Author(s).
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