A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Gene polymorphisms of IL-17A and bacterial meningitis in Angolan children
Tekijät: Teräsjärvi Johanna, Tenhu Elina, Cruzeiro Manuel Leite, Savonius Okko, Rugemalira Emilie, He Qiushui, Pelkonen Tuula
Kustantaja: Elsevier
Julkaisuvuosi: 2024
Journal: Infection, Genetics and Evolution
Tietokannassa oleva lehden nimi: Infection, Genetics and Evolution
Artikkelin numero: 105553
Vuosikerta: 118
ISSN: 1567-1348
eISSN: 1567-7257
DOI: https://doi.org/10.1016/j.meegid.2024.105553
Verkko-osoite: https://doi.org/10.1016/j.meegid.2024.105553
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/386811161
Interleukin (IL)-17 A plays a crucial role in protecting hosts from invading bacterial pathogens. In this study, we investigated if single nucleotide polymorphisms (SNPs) in IL-17A are associated with susceptibility and outcome of bacterial meningitis (BM) in Angolan children. The study sample comprised 241 confirmed BM patients and 265 controls, which were matched for age and ethnicity. Three IL-17A SNPs – rs2275913 (−197G > A), rs8193036 (-737C > T) and rs4711998 (−877 A > G) – were determined by high-resolution melting analysis (HRMA). The frequency of variant genotype rs4711998 was significantly higher in patients with BM caused by Haemophilus influenzae (odds ratio [OR] 3.5; 95% confidence interval [CI] 1.49–8.23; P = 0.0025) than in controls. Also, patients with BM caused by Gram-negative bacteria and who carried the variant genotype rs2275913 had a lower glucose level (P = 0.0051) in cerebrospinal fluid (CSF). Patients with BM caused by Streptococcus pneumoniae who carried the variant type rs8193036 had a reduced risk for severe neurological sequelae (OR: 0.14; 95% CI: 0.029–0.68; P = 0.0079), blindness (OR: 0.012; 95% CI: 0.012–0.87; P = 0.017) and ataxia (OR: 0.28; 95% CI: 0.091–0.83; P = 0.023). This study suggests an association of IL-17A genetic variations with susceptibility and outcome of bacterial meningitis in Angolan children.
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