A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Patient-reported outcomes in axial spondyloarthritis and psoriatic arthritis patients treated with secukinumab for 24 months in daily clinical practice
Tekijät: Christiansen Sara Nysom, Horskjær Rasmussen Simon, Pons Marion, Michelsen Brigitte, Glintborg Bente, Gudbjornsson Bjorn, Grondal Gerdur, Vencovsky Jiri, Loft Anne Gitte, Rotar Ziga, Pirkmajer Katja Perdan, Nissen Michael J., Baranová Jana, Macfarlane Gary J., Jones Gareth T., Iannone Florenzo, Caporali Roberto, Laas Karin, Vorobjov Sigrid, Giuseppe Daniela Di, Olofsson Tor, Provan Sella Aarrestad, Fagerli Karen Minde, Castrejon Isabel, Otero-Varela Lucia, van de Sande Marleen, van der Horst-Bruinsma Irene, Nordström Dan, Kuusalo Laura, Bernardes Miguel, Hetland Merete Lund, Østergaard Mikkel, Midtbøll Ørnbjerg Lykke
Kustantaja: Elsevier
Julkaisuvuosi: 2024
Journal: Seminars in Arthritis and Rheumatism
Tietokannassa oleva lehden nimi: Seminars in Arthritis and Rheumatism
Vuosikerta: 65
ISSN: 0049-0172
eISSN: 1532-866X
DOI: https://doi.org/10.1016/j.semarthrit.2024.152388
Verkko-osoite: https://doi.org/10.1016/j.semarthrit.2024.152388
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/386797110
Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates.
Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care were included. PRO remission rates were defined as pain, fatigue, Patient Global Assessment (PGA) ≤2 (Numeric Rating Scale (NRS) 0-10) and Health Assessment Questionnaire (HAQ) ≤0.5, for both axSpA and PsA, and were calculated as crude values and adjusted for drug adherence (LUNDEX). Comparisons of axSpA and PsA remission rates were performed using logistic regression analyses (unadjusted and adjusted for multiple confounders). Kaplan-Meier plots with log-rank test and Cox regression analyses were conducted to assess and compare secukinumab retention rates.
Results: We included 3087 axSpA and 3246 PsA patients initiating secukinumab. Crude pain, fatigue, PGA and HAQ remission rates were higher in axSpA than in PsA patients, whereas LUNDEX-adjusted remission rates were similar. No differences were found between the patient groups after adjustment for confounders. The 24-month retention rates were similar in axSpA vs. PsA in fully adjusted analyses (HR [95 %CI] = 0.92 [0.84-1.02]).
Conclusion: In this large European real-world study of axSpA and PsA patients treated with secukinumab, we demonstrate for the first time a comparable effectiveness in PRO remission and treatment retention rates between these two conditions when adjusted for confounders.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
