Fragmentation of thymidine induced by ultraviolet photoionization and thermal degradation



: Levola H, Kooser K, Rachlew E, Nommiste E, Kukk E

Publisher: ELSEVIER SCIENCE BV

: 2013

: International Journal of Mass Spectrometry

: INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

: INT J MASS SPECTROM

: 353

: 7

: 11

: 5

: 1387-3806

DOI: https://doi.org/10.1016/j.ijms.2013.08.008


Fragmentation of gas phase thymidine at different temperatures was studied with vacuum ultraviolet radiation and time-of-flight spectroscopy. Partial ion yield measurements were carried out in order to study the appearance energies of thymidine and its main fragments. The appearance energies of thymidine and its deoxyribose- and thymine-based fragments were determined to be 8.39, 8.77 and 8.81 eV, independently of temperature. The thermal decomposition of the sample was observed to start around 138-139 degrees C and it was explained by the breakage of the glycosidic bond, accompanied by hydrogen transfer from the deoxyribose ring to the thymine base. (C) 2013 Elsevier B.V. All rights reserved.



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