Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study

: Saari TI, Ihmsen H, Neuvonen PJ, Olkkola KT, Schwilden H

Publisher: OXFORD UNIV PRESS

: 2012

: British Journal of Anaesthesia

: BRITISH JOURNAL OF ANAESTHESIA

: BRIT J ANAESTH

: 3

: 108

: 3

: 491

: 498

: 8

: 0007-0912

DOI: https://doi.org/10.1093/bja/aer395

Age was found to be a significant covariate for oxycodone pharmacokinetics. In elderly patients, dosing should therefore be reduced and carefully titrated to avoid considerable accumulation of oxycodone and potentially hazardous side-effects.