A1 Refereed original research article in a scientific journal

Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study



Authors: Saari TI, Ihmsen H, Neuvonen PJ, Olkkola KT, Schwilden H

Publisher: OXFORD UNIV PRESS

Publication year: 2012

Journal: British Journal of Anaesthesia

Journal name in source: BRITISH JOURNAL OF ANAESTHESIA

Journal acronym: BRIT J ANAESTH

Number in series: 3

Volume: 108

Issue: 3

First page : 491

Last page: 498

Number of pages: 8

ISSN: 0007-0912

DOI: https://doi.org/10.1093/bja/aer395


Abstract
Age was found to be a significant covariate for oxycodone pharmacokinetics. In elderly patients, dosing should therefore be reduced and carefully titrated to avoid considerable accumulation of oxycodone and potentially hazardous side-effects.



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