Refereed journal article or data article (A1)

Late Blood Levels of Neurofilament Light Correlate With Outcome in Patients With Traumatic Brain Injury

List of AuthorsTuure Juho, Mohammadian Mehrbod, Tenovuo Olli, Blennow Kaj, Hossain Iftakher, Hutchinson Peter, Maanpää Henna-Riikka, Menon David K., Newcombe Virginia F., Takala Riikka S.K., Tallus Jussi, van Gils Mark, Zetterberg Henrik, Posti Jussi P.

PublisherMary Ann Liebert

Publication year2024

JournalJournal of Neurotrauma

Journal name in sourceJOURNAL OF NEUROTRAUMA

Journal acronymJ NEUROTRAUM

Volume number41

Issue number3-4

Start page359

End page368

Number of pages10





Neurofilament light (NF-L) is an axonal protein that has shown promise as a traumatic brain injury (TBI) biomarker. Serum NF-L shows a rather slow rise after injury, peaking after 1-2 weeks, although some studies suggest that it may remain elevated for months after TBI. The aim of this study was to examine if plasma NF-L levels several months after the injury correlate with functional outcome in patients who have sustained TBIs of variable initial severity. In this prospective study of 178 patients with TBI and 40 orthopedic injury controls, we measured plasma NF-L levels in blood samples taken at the follow-up appointment on average 9 months after injury. Patients with TBI were divided into two groups (mild [mTBI] vs. moderate-to-severe [mo/sTBI]) according to the severity of injury assessed with the Glasgow Coma Scale upon admission. Recovery and functional outcome were assessed using the Extended Glasgow Outcome Scale (GOSE). Higher levels of NF-L at the follow-up correlated with worse outcome in patients with moderate-to-severe TBI (Spearman's rho = -0.18; p < 0.001). In addition, in computed tomography-positive mTBI group, the levels of NF-L were significantly lower in patients with GOSE 7-8 (median 18.14; interquartile range [IQR] 9.82, 32.15) when compared with patients with GOSE <7 (median 73.87; IQR 32.17, 110.54; p = 0.002). In patients with mTBI, late NF-L levels do not seem to provide clinical benefit for late-stage assessment, but in patients with initially mo/sTBI, persistently elevated NF-L levels are associated with worse outcome after TBI and may reflect ongoing brain injury.

Last updated on 2024-13-02 at 17:53