A1 Refereed original research article in a scientific journal

Optimising the antibiotic treatment of uncomplicated acute appendicitis: a protocol for a multicentre randomised clinical trial (APPAC II trial)



Authors: Haijanen J, Sippola S, Grönroos J, Rautio T, Nordström P, Rantanen T, Aarnio M, Ilves I, Hurme S, Marttila H, Virtanen J, Mattila A, Paajanen H, Salminen P; and on behalf of the APPAC study group

Publication year: 2018

Journal: BMC Surgery

Article number: 117

Volume: 18

Number of pages: 11

ISSN: 1471-2482

DOI: https://doi.org/10.1186/s12893-018-0451-y

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/38132282


Abstract
Discussion

To our knowledge, APPAC II trial is the first randomised controlled trial comparing per oral antibiotic monotherapy with intravenous antibiotic therapy continued by per oral antibiotics in the treatment of uncomplicated acute appendicitis. The APPAC II trial aims to add clinical evidence on the debated role of antibiotics as the first-line treatment for a CT-confirmed uncomplicated acute appendicitis as well as to optimise the non-operative treatment for uncomplicated acute appendicitis.


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Last updated on 2024-26-11 at 22:55