A1 Refereed original research article in a scientific journal
Stress Biology : Complexity and Multifariousness in Health and Disease
Authors: Mayer Matthias P., Blair Laura, Blatch Gregory L., Borges Thiago J., Chadli Ahmed, Chiosis Gabriela, de Thonel Aurélie, Dinkova-Kostova Albena, Ecroyd Heath, Edkins Adrienne L., Eguchi Takanori, Fleshner Monika, Foley Kevin P., Fragkostefanakis Sotirios, Gestwicki Jason, Goloubinoff Pierre, Heritz Jennifer A., Heske Christine M., Hibshman Jonathan D., Joutsen Jenny, Li Wei, Lynes Michael, Mendillo Marc L., Mivechi Nahid, Mokoena Fortunate, Okusha Yuka, Prahlad Veena, Repasky Elizabeth, Sannino Sara, Scalia Federica, Shalgi Reut, Sistonen Lea, Sontag Emily, van Oosten-Hawle Patricija, Vihervaara Anniina, Wickramaratne Anushka, Wang Shawn Xiang Yang, Zininga Tawanda
Publisher: Elsevier
Publication year: 2024
Journal: Cell Stress and Chaperones
Journal name in source: Cell Stress and Chaperones
Volume: 29
Issue: 1
First page : 143
Last page: 157
ISSN: 1355-8145
eISSN: 1466-1268
DOI: https://doi.org/10.1016/j.cstres.2024.01.006
Web address : https://doi.org/10.1016/j.cstres.2024.01.006
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/381278099
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response (HSR), unfolded protein response (UPR) and integrated stress response (ISR), that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate expression of most genes but increase expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in repair of stress-induced damage to macromolecules and cellular structures. 61 years after the discovery of the heat shock response by Ferruccio Ritossa many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
Downloadable publication This is an electronic reprint of the original article. |  |
