Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent

Tekijät: Atsushi Mahara, Jun‐ichiro Enmi, Yu‐I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka

Julkaisuvuosi: 2018

Journal: Macromolecular Bioscience

Lehden akronyymi: Macromol Biosci

Vuosikerta: 18

Numero: 5

Aloitussivu: e1700391

Sivujen määrä: 11

ISSN: 1616-5187

eISSN: 1616-5195

DOI: https://doi.org/10.1002/mabi.201700391

Verkko-osoite: https://www.myendnoteweb.com/EndNoteWeb.html?SrcApp=WOK&SID=F4xltZNZ63ChsAyNnEG

Tiivistelmä

Magnetic resonance angiography is an attractive method for the visualization of the cerebrovasculature, but small-sized vessels are hard to visualize with the current clinically approved agents. In this study, a polymeric contrast agent for the superfine imaging of the cerebrovasculature is presented. Eight-arm polyethylene glycol with a molecular weight of ≈17 000 Da conjugated with a Gd chelate and fluorescein (F-8-arm PEG-Gd) is used. The relaxivity rate is 9.3 × 10