A1 Journal article – refereed
Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent
List of Authors: Atsushi Mahara, Jun‐ichiro Enmi, Yu‐I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka
Publication year: 2018
Journal: Macromolecular Bioscience
Journal acronym: Macromol Biosci
Volume number: 18
Issue number: 5
Number of pages: 11
ISSN: 1616-5187
eISSN: 1616-5195
DOI: http://dx.doi.org/10.1002/mabi.201700391
URL: https://www.myendnoteweb.com/EndNoteWeb.html?SrcApp=WOK&SID=F4xltZNZ63ChsAyNnEG
Magnetic resonance angiography is an attractive method for the visualization of the cerebrovasculature, but small-sized vessels are hard to visualize with the current clinically approved agents. In this study, a polymeric contrast agent for the superfine imaging of the cerebrovasculature is presented. Eight-arm polyethylene glycol with a molecular weight of ≈17 000 Da conjugated with a Gd chelate and fluorescein (F-8-arm PEG-Gd) is used. The relaxivity rate is 9.3 × 10
