Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent - UTU Research Portal

A1 Refereed original research article in a scientific journal

Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent

Authors: Atsushi Mahara, Jun‐ichiro Enmi, Yu‐I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka

Publication year: 2018

Journal: Macromolecular Bioscience

Journal acronym: Macromol Biosci

Volume: 18

Issue: 5

First page : e1700391

Number of pages: 11

ISSN: 1616-5187

eISSN: 1616-5195

DOI: https://doi.org/10.1002/mabi.201700391

Web address : https://www.myendnoteweb.com/EndNoteWeb.html?SrcApp=WOK&SID=F4xltZNZ63ChsAyNnEG

Abstract

Magnetic resonance angiography is an attractive method for the visualization of the cerebrovasculature, but small-sized vessels are hard to visualize with the current clinically approved agents. In this study, a polymeric contrast agent for the superfine imaging of the cerebrovasculature is presented. Eight-arm polyethylene glycol with a molecular weight of ≈17 000 Da conjugated with a Gd chelate and fluorescein (F-8-arm PEG-Gd) is used. The relaxivity rate is 9.3 × 10