A1 Refereed original research article in a scientific journal

Strong regulatory graphs




AuthorsGustafsson, Patric; Petre, Ion

PublisherIOS Press

Publication year2024

JournalFundamenta Informaticae

Volume19

Issue3-4

First page 299

Last page314

eISSN1875-8681

DOIhttps://doi.org/10.3233/FI-242184

Web address https://doi.org/10.3233/FI-242184

Self-archived copy’s web addresshttps://arxiv.org/pdf/2306.08261

Preprint addresshttps://arxiv.org/abs/2306.08261


Abstract

Logical modeling is a powerful tool in biology, offering a system-level understanding of the complex interactions that govern biological processes. A gap that hinders the scalability of logical models is the need to specify the update function of every vertex in the network depending on the status of its predecessors. To address this, we introduce in this paper the concept of strong regulation, where a vertex is only updated to active/inactive if all its predecessors agree in their influences; otherwise, it is set to ambiguous. We explore the interplay between active, inactive, and ambiguous influences in a network. We discuss the existence of phenotype attractors in such networks, where the status of some of the variables is fixed to active/inactive, while the others can have an arbitrary status, including ambiguous.



Last updated on 2024-26-11 at 10:43