A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia
Tekijät: Hoogewijs D, Terwilliger NB, Webster KA, Powell-Coffman JA, Tokishita S, Yamagata H, Hankeln T, Burmester T, Rytkonen KT, Nikinmaa M, Abele D, Heise K, Lucassen M, Fandrey J, Maxwell RH, Pahlman S, Gorr TA
Kustantaja: OXFORD UNIV PRESS INC
Julkaisuvuosi: 2007
Journal: Integrative and Comparative Biology
Tietokannassa oleva lehden nimi: INTEGRATIVE AND COMPARATIVE BIOLOGY
Lehden akronyymi: INTEGR COMP BIOL
Vuosikerta: 47
Numero: 4
Aloitussivu: 552
Lopetussivu: 577
Sivujen määrä: 26
ISSN: 1540-7063
DOI: https://doi.org/10.1093/icb/icm072
The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.
