From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia - UTU Research Portal

A2 Refereed review article in a scientific journal

From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Authors: Hoogewijs D, Terwilliger NB, Webster KA, Powell-Coffman JA, Tokishita S, Yamagata H, Hankeln T, Burmester T, Rytkonen KT, Nikinmaa M, Abele D, Heise K, Lucassen M, Fandrey J, Maxwell RH, Pahlman S, Gorr TA

Publisher: OXFORD UNIV PRESS INC

Publication year: 2007

Journal: Integrative and Comparative Biology

Journal name in source: INTEGRATIVE AND COMPARATIVE BIOLOGY

Journal acronym: INTEGR COMP BIOL

Volume: 47

Issue: 4

First page : 552

Last page: 577

Number of pages: 26

ISSN: 1540-7063

DOI: https://doi.org/10.1093/icb/icm072

Abstract

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.