Integrin trafficking in cells and tissues



: Paulina Moreno-Layseca, Jaroslav Icha, Hellyeh Hamidi, Johanna Ivaska

: 2019

: Nature Cell Biology

: Nature cell biology

: Nat Cell Biol

: 21

: 2

: 122

: 132

: 11

: 1465-7392

: 1476-4679

DOI: https://doi.org/10.1038/s41556-018-0223-z


Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.



Last updated on 2024-26-11 at 11:07